I expect very tight battle at Stade Gerland in Lyon. Real Madrid is favorite according to the bookmakers, but I am sure it won't be easy for Real. In fact, Lyon is probably the only European team with such impressive score against Real Madrid. Just look the last six mutual games, all in Champions League:

Champions League 2009/10
10.03.2010. Real Madrid - Lyon 1:1
16.02.2010. Lyon - Real Madrid 1:0

Champions League 2006/07
21.11.2006. Real Madrid - Lyon 2:2
13.09.2006. Lyon - Real Madrid 2:0

Champions League 2005/06��� �
23.11.2005. Real Madrid - Lyon 1:1
13.09.2005. Lyon - Real Madrid 3:0

As You can see Real lost three games and played draw in the remaining three games. I am sure coach Jose Mourinho will be very careful now in order the history not to be repeated. For this game Real is boosted by returning of first goalkeeper Iker Casillas. He didn't play against Levante in Primera as he was suspended. However the second keeper Dudek and striker Higuain are injured. The situation in Lyon squad is much worse. Coach Claude Puel will be without injured Lisandro Lopez and Ederson, while Hugo Lloris is doubtful.

I expect both teams to play very carefully. The first task will be not to receive a goal, and just after that to try to score. Mourinho will play with only one striker and it seems that will be Adebayor. In situation like this I expect maximum two goals here.