Vicenza is strong favorite here. The main reason is difference between two teams. The quality is on Vicenza side and only some undersetimation could give a chance to benevento. But not only the quality is reason for my pick. According to the information on the web, Benevento will travel to Vicenza with bus. It is not a pleasent trip when You have to do this. Only 18 players are in contention, most of them youngsters. On contrary, Vicenza will play this game with the strongest squad. Here are the starting eleven for both teams:

Vicenza: Russo, Martinelli, Zanchi, Tonucci, Giani, Paro, Soligo, Botta, Di Matteo, Sgrigna, Baclet
Benevento: Aldegani, Pedrelli, Siniscalchi, Signorini, Palermo, Pintori, Vacca, Carcione, La Camera, Clemente, Evacuo

So, Vicenza should win this game. It is clear Benevento have no ambitions in the cup and their only target will be the championship. Vicenza is Serie B team, while Benevento will play in Pro Divisione (something like third division). So, home win is very possible here.